Named the danger of popular household goods


Scientists at Washington University in St. Louis found that triclosan - a component of antibacterial agents and other household goods - makes microbes immune to the action of antibiotics. At the same time, bacteria can survive even lethal concentrations of drugs, including those used in urinary tract infection. This is reported in a press release on Phys.org. This is reported by Rambler.

In the new work, researchers demonstrated how exposure to triclosan affects the body's ability of mice to respond to antibiotics during infection. One group of rodents was exposed to triclosan prior to the introduction of the bactericidal drug ciprofloxacin, and the other group was treated only with antibiotics. Ciprofloxacin is the most commonly used agent for bacterial lesions of the urinary tract.

The results of measuring the content of triclosan in the urine of rodents showed that its level is similar to that observed in humans. In this case, the disinfectant increased the number of bacteria cells in the bladder that survived with further treatment. Normally, one of the million microorganisms should remain, but in this case one out of ten microbes could withstand the effects of ciprofloxacin. This is reported by Rambler.

Scientists have found that triclosan affects the activity of the ppGpp molecule, which is an inhibitor of cell growth. During stress, ppGpp stops the biosynthesis of cellular components (DNA, RNA, proteins), redirecting resources to ensure survival. Therefore, drugs that slow down the growth of bacteria cannot be taken before antibiotics, which can become ineffective. The absence of ppGpp has been shown to deprive triclosan of its ability to induce resistance to treatment. This is reported by Rambler.

Triclosan is found in a variety of consumer products. It is added to toothpaste, mouthwash, cosmetics, clothing, children's toys and credit cards in order to prevent the growth of bacteria. This is reported by Rambler.

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